2014

 

152. Bourguet, C.B.; Claing, A.; Laporte, S.; Hébert, T.E.; Chemtob, S.; Lubell, W.D. "Synthesis of azabicycloalkanone amino acid and aza-peptide mimics, and their application as modulators of the prostaglandin-F2α receptor for delaying preterm birth" Can. J. Chem., 2014, 92 (11), 1031-1040. https://doi.org/10.1139/cjc-2014-0289

 

151. Traoré, M.; Doan, N.-D.; Lubell, W. D. "Diversity-Oriented Synthesis of Azapeptides with Basic Amino Acid Residues: Aza-Lysine, Aza-Ornithine and Aza-Arginine" Org. Lett., 2014, 16 (13), 3588–3591. DOI: 10.1021/ol501586y

 

150. Bourguet, C. B.; Boulay, P.-L.; Claing, A.; Lubell, W. D. “Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells" Bioorg. Med. Chem. Lett. 2014, 24 (15), 3361–3365. https://doi.org/10.1016/j.bmcl.2014.05.095

 

149. Doan, N.-D.; Hopewell, R.; Lubell, W. D. “N-Aminoimidazolidin-2-one Peptidomimetics” Org. Lett., 2014, 16 (8), 2232–2235.

DOI: 10.1021/ol500739k

 

148. Zhang, J.; Proulx, C.; Tomberg, A.; Lubell, W.D. “Multicomponent Diversity-Oriented Synthesis of Aza-Lysine-Peptide Mimics” Org. Lett., 2014, 16 (8), 298–301. DOI: 10.1021/ol403297v

 

147. Dörr, A. A.; Lubell, W.D. “Aminophenylpyrrole synthesis and application to pyrrolo[1,2-c]quinazolinone synthesis” Heterocycles 2014, 88 (2), 1149-1161, Victor Snieckus's Special Issue. DOI: 10.3987/COM-13-S(S)73

 

146. Proulx, C.; Lubell, W. D., “Analysis of N-amino-imidazolin-2-one peptide turn mimic 4-position substituent effects on conformation by X-ray crystallography.” Biopolymers, Peptide Science, 2014, 102 (1), 7-15. DOI: 10.1002/bip.22327

 

145. Saroukou, M.S.M.; Skalski, T.; Skene, W. G.; Lubell, W. D. “Conjugated C3 symmetric aryl tripyrroles and aryl bipyrroles:  synthesis, optical and electronic properties” Tetrahedron 2014, 70, 450–458. https://doi.org/10.1016/j.tet.2013.11.043

 

144. Khashper, A.; Lubell, W. D. “Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics” Org. Biomol. Chem. 2014, 12, 5052-5070. DOI: 10.1039/C4OB00777H

 

2013

 

143. Bouayad-Gervais, S. H.; Lubell, W. D. “Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame” Molecules 2013, 18, 14739-14746. doi:10.3390/molecules181214739

 

142. Garcia-Ramos, Y.; Lubell, W., D. “Synthesis and alkylation of aza-glycinyl dipeptide building blocks” J. Peptide Sci. 2013, 19 (12), 725-729.

DOI: 10.1002/psc.2572

 

141. Rivera, J.-C.; Sitaras, N.; Noueihed, B.; Hamel, D.; Madaan, A.; Zhou, T.; Honoré, J.-C.; Quiniou, C.; Joyal, J.-S.; Hardy, P.; Sennlaub, F.; Lubell, W.; Chemtob, S. “Microglia and IL-1β in ishchemic retinopathy elicit microvascular degeneration through neuronal semaphoring 3A” Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33, 1881-1891. https://doi.org/10.1161/ATVBAHA.113.301331

 

140. Leduc M, Hou X, Hamel D, Sanchez M, Honoré J-C, Lubell W, Varma DR, Mancini J, Peri KG, Heveker N, Chemtob S. “Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.” Am. J. Physiol. Regul. Integr. Comp. Physiol. 304:R10-R22, 2013. doi:  10.1152/ajpregu.00138.2012

 

139. Jamieson, A. G.; Sabatino, D.; Boutard, N.;  Lubell, W. D. “Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery” Chem. Bio. Drug Design 2013, 81, 148-165. DOI: 10.1111/cbdd.12042

 

2012

 

138. Garcia-Ramos, Y.; Proulx, C.; Lubell, W., D. “Synthesis of hydrazine and azapeptide derivatives by alkylation of carbazates and semicarbazones” Can. J. Chem., 2012, 90, 985-993. https://doi.org/10.1139/v2012-070

 

137. Proulx, C.; Lubell, W., D. “N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis” Org. Lett., 2012, 14, 4552–4555.  DOI: 10.1021/ol302021n

 

136. Quiniou C, Goupil E, Lubell W, Laporte S, Chemtob S. “Découver te de modulateurs allostériques  peptidiques de récepteurs  transmembranaires: focus sur la sélectivité fonctionnelle” Médecine Sci. Am. 1:123-138, 2012. http://s3.amazonaws.com/msamerique/documents/52/original/MSA2012-07%20.pdf?1342038798

 

135. Proulx, C.; Picard, E.; Boeglin, B.; Pohankova,  P.; Chemtob,  S.; Ong,  H.; Lubell,  W.,  D. “Azapeptide Analogues of GHRP-6 as Cluster of Differentiation 36 Receptor Ligands with Reduced Affinity for the Growth Hormone Secretagogue Receptor 1a.” J. Med. Chem. 2012, 55, 6502–6511. DOI: 10.1021/jm300557t

 

134. Dörr, A. A.; Lubell, W.D. “Synthesis of Protected 2-Pyrrolylalanine for Peptide Chemistry and Examination of Its Influence on Prolyl Amide Isomer Equilibrium” J. Org. Chem. 2012, 77, 6414–6422.  DOI: 10.1021/jo3005809

 

133. Spiegel, J.; Mas-Moruno, C.; Kessler, H.; Lubell, W.D. "Cyclic aza-peptide integrin ligand synthesis and biological activity" J. Org. Chem. 2012, 77, 5271–5278.  DOI: 10.1021/jo300311q

 

132. Gnaccarini, C.; Ben-Tahar, W.; Mulani, A.; Roy, I.; Lubell, W.D.; Pelletier, J.N.; Keillor, J.W. "Site-specific protein propargylation using tissue transglutaminase" Org. Biomol. Chem., 2012, 10, 5258-5265. http://dx.doi.org/10.1039/C2OB25752A

 

131. Turcotte, S.; Bouayad-Gervais, S.H.; Lubell, W.D. “N-Aminosulfamide Peptide Mimic Synthesis by Alkylation of Aza-sulfurylglycinyl Peptides” Org. Lett. 2012, 14, 1318–1321. DOI: 10.1021/ol3001987

 

2011

 

130. Tshibaka, T.; Bishop, S.; Roche, I.U.; Dufresne, S.; Lubell, W.D.; Skene, W.G. “Conjugated 4-methoxybipyrrole thiophene azomethines: synthesis, opto-electronic properties and crystallographic characterization” Chem. Eur. J. 2011, 17, 10879 – 10888.

 

129. Bourguet, C.; Goupil, E.; Tassy, D.; Hou, W.; Thouin, E.; Polyak, F.; Hebert, T. E.; Claing, A.; Laporte, S. A. ; Chemtob, S.; Lubell, W. D. "Targeting the Prostaglandin F2α Receptor for Preventing Preterm Labor with Azapeptide Tocolytics" J. Med. Chem. 2011, 54, 6085–6097.

 

128. Sabatino, D., Proulx, C., Pohankova, P., Ong, H., Lubell, W.D.  “Structure-Activity Relationships of GHRP-6 Azapeptide Ligands of the CD36 Scavenger Receptor by Solid-Phase Submonomer Azapeptide Synthesis ” J. Am. Chem. Soc. 2011, 133, 12493–12506.

 

127. Godina, T. A.; Lubell, W. D. “Mimics of Peptide Turn Backbone and Side-Chain Geometry by a General Approach for Modifying Azabicyclo[5.3.0]alkanone Amino Acids” J. Org. Chem. 2011, 76, 5846–5849.

       

126. Bolduc, O. R.; Lambert-Lanteigne, P.; Colin, D. Y.; Zhao, S.S; Proulx, C.; Boeglin, D.; Lubell, W. D.; Pelletier, J. N.; Féthière, J.; Ong, H.; Masson, J.-F. “Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors” Analyst, 2011 136, 3142-3148.

 

125. Boutard, N.; Dufour-Gallant, J.; Deaudelin, P.; Lubell, W.D. “Pyrrolo[3,2-e][1,4]diazepin-2-one Synthesis: A Head-to-Head Comparison of Soluble versus Insoluble Supports” J. Org. Chem. 2011, 76, 4533–4545.

 

124. Proulx, C.; Sabatino, D.; Hopewell, R.; Spiegel, J.; García-Ramos, Y.; Lubell, W.D. “Azapeptides and their therapeutic potential: current issues and new possibilities” Future Med. Chem. 2011, 1139–1164. doi: 10.4155/fmc.11.74

 

123. Boutard, N.; Turcotte, S.; Beauregard, K.; Quiniou, C.; Chemtob, S. Lubell, W.D. “Examination of the Active Secondary Structure of the Peptide APG-101.10, an Allosteric Modulator of the Interleukin-1 Receptor, by Positional Scanning Using b-Amino g-Lactams” J. Peptide Sci. 2011, 17, 288–296.

 

122. Dörr, A. A.; Lubell, W. D. “Synthesis and peptide coupling of protected 2-pyrrolylalanine” Tetrahedron Letters 2011, 52, 2159-2161.

 

2010

 

121. Picard, E.; Houssier, M.; Bujold, K.; Sapieha, P.; Lubell, W.; Dorfman, A.; Racine, J.; Hardy, P.; Febbraio, M.; Lachapelle, P.; Ong, H.; Sennlaub, F.; Chemtob, S. “CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposit.” Aging 2010, 12, 981-9.

 

120. St-Cyr, D. J.; Maris, T.; Lubell, W. D. “Conformational analysis of hydroxylactam dipeptides as constrained Ser/Thr peptide mimics.” Heterocycles 2010, 82, 729-737.

 

119. Proulx, C.; Lubell, W. D. “Aza-1,2,3-triazole-3-alanine Synthesis via Copper-catalyzed 1,3-Dipolar Cycloaddition on Aza-progargylglycine” J. Org. Chem. 2010, 75, 5385-5387.

 

118. Proulx, C.; Lubell, W. D.  "Copper-Catalyzed N-Arylation of Semicarbazones for the Synthesis of Aza-arylglycine-Containing Aza-Peptides" Org. Lett. 2010, 12, 2916-2919.

 

117. Kassem, T.; Zhu, X.X.; Lubell, W.D. “Poly(vinyl alcohol)-graft-poly(ethylene glycol)-supported hydroxyproline catalysis of stereoselective aldol reactions" Macromol. Symp. 2010, 297, 101-107.

 

116. Goupil, E.; Tassy, D.; Bourguet, C.; Quiniou, C.; Wisehart, V.; Pétrin, D.; Le Gouill, C.; Devost, D.; Zingg, H. H.; Bouvier, M.; Saragovi, H. U.; Chemtob, S.; Lubell, W. D.; Claing, A.; Hebert, T. E.; Laporte, S. A. “­A novel biased allosteric compound inhibitor of parturition, selectively impedes the PGF2a-mediated Rho/Rock signaling pathway” J. Biol. Chem. 2010, 285, 25624-25636.

 

115. Bourguet, C.B.; Sabatino, D.; Proulx, C.; Klocek, S.; Lubell, W.D. " Solution-phase sub-monomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-diketopiperazine synthesis.” J. Peptide Sci. 2010, 16, 284-296.

 

114. St.-Cyr, D.; Jamieson, A. G.; Lubell, W.D. "α-Amino-β-hydroxy-γ-lactams, constrained serine and threonine dipeptide mimics" Org. Lett. 2010, 12 (8), 1652–1655.

 

113. Tong, W.; Gagnon, M.; Sprules, T.; Gilbert, M.; Chowdhury, S.; Meerovitch, K.; Hansford, K.; Purisima, E. O.; Blankenship, J. W.; Cheung, N.-K. V.; Gehring, K.; Lubell, W. D.; Saragovi, H. U.; "Small Molecule Ligands of GD2 Ganglioside, Designed from NMR Studies, Exhibit Induced-Fit Binding and Bioactivity." Chemistry & Biology, 2010, 17 (2), 183-194.

 

112. Ronga, L.; Jamieson, A. G.; Beauregard, K.; Quiniou, C.; Chemtob, S.; Lubell, W.D. "Insertion of Multiple alpha-Amino gamma-Lactam (Agl) Residues into a Peptide Sequence By Solid-Phase Synthesis on SynPhase Lanterns” Biopolymers, Peptide Science 2010, 94 (2), 183 - 191.

 

111. Boutard, N.; Jamieson, A. G.; Ong, H.; Lubell, W.D. "Structure-Activity Analysis of the Growth Hormone Secretagogue GHRP-6 by α− and β−Amino γ−Lactam Positional Scanning" Chemical Biology and Drug Design 2010, 75 (1), 40-50.

 

2009

 

110. Tshibaka, T.; Roche Ulliel, I.; Dufresne, S.; Lubell, W. D.; Skene, W. G. "Unsymmetric Electronic Push-Pull Bipyrroles – Synthesis, Spectroelectrochemical, and Photophysical Investigation" J. Org. Chem. 2009, 74 (24), 9497–9500.

 

109. Sabatino, D.; Proulx, C.; Klocek, S.; Bourguet, C.B.; Boeglin, D. Ong, H.; Lubell, W.D. “Side-Chain Diversity by Submonomer Solid-Phase Synthesis of Aza-Peptides” Org. Lett. 2009, 11, 3650-3653.

 

108. Gnaccarini, C.; Ben-Tahar, W.; Pelletier, J.; Lubell, W.D.; Keillor, J.W. “Fluorometric Assay for Transglutaminase-Mediated Transamidation Activity” Bioorg. Med. Chem. 2009, 17, 6354-6359.

 

107. Rihakova, L.; Quiniou, C.; Hamdan, F.; Kaul, R.; Brault, S.; Hou, X.; Lahaie, I.; Sapieha, P.; Gobeil F Jr.; Hardy, P.; Bouvier, M.; Saragovi, H.; Varma, D. R.; Heveker, N.; Guillon, G.; Lubell, W.D.; Chemtob, S. “VRQ397 (CRAVKY): a novel non-competitive V2 receptor antagonist” Am. J. Physiol. Regulatory Integrative Comp. Physiol., Oct 2009; 297: R1009 - R1018.

 

106. Kassem, T.; Sabatino, D.; Jia, X.; Zhu, X.X.; Lubell, W.D. “To Rink or not to Rink amide link, that is the question to address for more economical and environmentally sound solid-phase peptide synthesis” Int. J. Peptide Res. Therapeutics 2009, 15, 211–218.

 

105. Jamieson, A. G.; Boutard, N.; Beauregard, K.; Bodas, M.B; Ong, H.; Quiniou, C.; Chemtob, S.; Lubell, W.D. “Positional Scanning for Peptide Secondary Structure by Systematic Solid-Phase Synthesis of Amino-Lactam Peptides” J. Am. Chem. Soc. 2009, 131, 7917–7927.

 

104. Fridkin, G.; Boutard, N.; Lubell, W.D. “β,β-Disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives”. J. Org. Chem. 2009, 74, 5603–5606.

 

103. Pardin, C.; Roy, I.; Chica, R. A.; Bonneil, E.; Thibault, P.; Pelletier, J. N.; Keillor, J. W.; Lubell, W. D. “Photolabeling of Tissue Transglutaminase Reveals Binding Mode of Potent Cinnamoyl Inhibitors” Biochemistry, 2009, 48 (15), 3346–3353.

 

2008

 

102. Quiniou, C.; Kooli, E.; Joyal, J-S.;Sapieha, P.; Sennlaub, F.; Lahaie, I.;  Zhuo, S.; Hou, X.; Hardy, P.; Lubell, W.; Chemtob, S. “Interleukin-1 and Ischemic Brain Injury in the Newborn: Development of a Small Molecule Inhibitor of IL-1 Receptor” Semin. Perinatol. 2008, 32, 325-333.

 

101. Bourguet, C. B.; Sabatino, D.; Lubell, W. D. “Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides” Biopolymers, Peptide Science 2008, 90, 824-831.

 

100. Pardin, C.; Roy, I.; Keillor, J. W.; Lubell, W. “Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase” Chemical Biology and Drug Design 2008, 72, 189-196.

 

99. Iden, H. S.; Lubell, W. D. “1,3,5-Tri- and 1,3,4,5-Tetra-substituted 1,4-Diazepin-2-one Solid-Phase Synthesis”, J. Comb. Chem. 2008, 10, 691-699.

 

98. Deaudelin, P.; Lubell, W.D. “Diastereoselective Pictet-Spengler approach for the synthesis of pyrrolo[3,2-e][1,4]-diazepin-2-one peptide turn mimics” Org. Lett. 2008, 10, 2841-2844.

 

97. Galaud, F., Blankenship, J.W.; Lubell, W.D. “Crystal Structure Analyses and Reactivity of N-Alkyl and N-Acyl-Dioxathiazinanes” Heterocycles 2008, 76, 1121-1131.

 

96. Quiniou, C.; Lahaie, I.; Hou, X.; Brault, S.; Beauchamp, M.; Leduc, M.; Heveker, N.; Lubell, W. D.; Sennlaub, F.; Phezhetsky, A,; Chemtob, S. “Characterization of a novel allosteric antagonist of Interleukin-1 receptor: 101.10” The Journal of Immunology, 2008, 180, 6977-6987.

 

95. Pardin, C.; Chica, R. A.; Pelletier, J. N.; Keillor, J. W.; Lubell, W. D. “Cinnamoyl inhibitors of tissue transglutaminase” J. Org. Chem. 2008, 73, 5766-5775.

 

94. Keillor, J. W.; Chica, R. A.; Chabot, N.; Vinci, V.; Pardin, C.; Fortin, E.; Gillet, S.M.F.G.; Nakano, Y.; Kaartinen, M. T.; Pelletier, J. N.; Lubell, W. D. “The bioorganic chemistry of transglutaminase – from mechanism to inhibition and engineering” Can. J. Chem. 2008, 86, 271-276.

 

93. Fridkin, G.; Lubell, W.D. “2-Vinylpyrroles and pyrrolo[3,2-d]pyrimidines from direct addition of aldehydes to 4-amino-pyrrole-2-carboxylate derivatives.” Org. Lett. 2008, 10 (5), 849-852.

 

92. Jolicoeur, B.; Lubell, W.D. “Prodigiosin Synthesis with Electron Rich 2,2’-Bipyrroles" Can. J. Chem. 2008, 86, 213-218.

 

2007

 

91. Dörr, A.; Lubell, W.D. “Homoallylic Ketones and Pyrroles by way of Copper-Catalyzed Cascade Additions of Alkyl-Substituted Vinyl Grignard Reagents to Esters” Can. J. Chem. 2007, 85, 1006-1017.

 

90. Iden, H. S.; Lubell, W.D. “1,3,5-Trisubstituted 1,4-Diazepin-2-ones” J. Org. Chem. 2007, 72, 8980-8983.

 

89. Luo, J.; Pardin, C.; Zhu, X.X.; Lubell, W.D. “Preparation, Characterization and Application of Poly(viny alcohol)–graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid Phase Synthesis” J. Comb. Chem. 2007, 9, 582-591.

 

88. Lama, T.; Seaman, S. E.; Genest, N.; Lubell, W.D. “Importance of the Central Amide in Beta-Turns, Synthesis of Pro-Aib Hydroxyethylene Isosteres and Analysis in Model Beta-Turn Peptides” International Journal of Peptide Research and Therapeutics 2007, 13, 355-366.

 

87. Luo, J.; Pardin, C.; Zhu, X.X.; Lubell, W.D. “Poly(vinyl alcohol)–graft-Poly(ethylene glycol) Resins and their use in Solid-Phase Synthesis and Supported TEMPO Catalysis” Chem. Commun. 2007, 22, 2136-2138.

 

86. Dörr, A.; Lubell, W.D. “Synthesis of a new p-Defficient Phenylalanine Derivative from a Common 1,4-Diketone Intermediate and Study of the Influence of Aromatic Density on Prolyl Amide Isomer Population” Biopolymers, Peptide Science 2007, 88, 290-299.

 

85. Rao, M.H.V.R.; Pinyol, E.O.; Lubell, W.D. “Rigid Dipeptide Mimetics: Synthesis of Enantiopure C6-Functionalized Pyrrolizidinone Amino Acids”, J. Org. Chem. 2007, 72, 736-743.

 

84. Boeglin, D.; Hamdan, F.F.; Melendez, R.E.; Cluzeau, J.; Laperriere, A.; Bouvier, M.; Lubell, W.D. "CGRP Analogs with Aza- and Indolizidione Amino Acid Residues Reveal Conformational Requirements for Antagonist Activity at the Human Calcitonin Gene-Related Peptide 1 Receptor", J. Med. Chem. 2007, 50, 1401-1408.

 

2006

 

83. Jolicoeur, B.; Lubell, W.D. "4-Alkoxy and 4-Amino 2,2’-Bipyrrole Synthesis" Org. Lett. 2006, 8, 6107-6110.

 

82. Iden, H. S.; Lubell, W.D. “1,4-Diazepinone and Pyrrolodiazepinone Syntheses via Homoallylic Ketones from Cascade Addition of Vinyl Grignard Reagent to α-Aminoacyl-β-amino Esters” Org. Lett. 2006, 8, 3425-3428.

 

81. Boeglin, D.; Xiang, Z.; Sorenson, N.B.; Wood, M.S.; Haskell-Luevano, C.; Lubell, W.D. “Aza-scan of the Potent Melanocortin Receptor Agonist Ac-His-d-Phe-Arg-Trp-NH2” Chem. Biol. Drug Des. 2006, 67, 275–283.

 

80. Surprenant, S.; Lubell, W. D. “From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids: A Transannular Cyclization Route for Peptide Mimic Synthesis” Org. Lett. 2006, 8, 2851-2854.

 

79. Surprenant, S.; Lubell, W. D. “9-(4-Bromophenyl)-9-fluorenyl as a Safety-Catch Nitrogen Protecting Group” J. Org. Chem. 2006, 71 (2), 848-851.

 

78. Brouillette, Y.; Rombouts, F. J. R.; Lubell, W. D. "Solid-Phase Synthesis of 3-Aminopyrrole-2,5-dicarboxylate Analogs" J. Comb. Chem. 2006, 8 (1), 117-126.

 

77. B. Jolicoeur, E. E. Chapman, A. Thompson, and W. D. Lubell “Pyrrole Protection” Tetrahedron 2006, 62, 11531-11563.

 

2005

 

76. Hansford, K. A.; Guarin, S. A. P., Skene, W. G.; Lubell, W. D. "Bis(pyrrol-2-yl)arylenes from the Tandem Bi-directional Addition of Vinyl Grignard Reagent to Aryldiesters" J. Org. Chem. 2005, 70, 7996-8000.

 

75. Boeglin, D.; Lubell, W. D. "Aza-Amino Acid Scanning of Secondary Structure Suited for Solid-Phase Peptide Synthesis with Fmoc Chemistry and Aza-Amino Acids with Heteroatomic Side-Chains"  J. Comb. Chem. 2005, 7 (6), 864-878.

 

74. Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: Combinatorial synthesis of a library of N3, N5, C6 trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7 (6), 977-986.

 

73. Rombouts, F. J. R.; Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7, 589-598.

 

72. Kaul, R.; Surprenant, S. Lubell, W. D. "Systematic Study of the Synthesis of Macrocyclic Dipeptide Beta-Turn Mimics Possessing 8-, 9- and 10- Membered Rings by Ring Closing Metathesis" J. Org. Chem. 2005, 70, 3838-3844 and addition/correction 2005; 70 (12), 4901-4902.

 

71. Galaud, F.; Lubell, W. D. "Homoserine-Derived Cyclic Sulfamidate as Chiral Educt for The Diversity Oriented Synthesis of Lactam-Bridged Dipeptides" Biopolymers, Peptide Science, 2005, 80, 665-674.

 

70. Sajjadi, Z.; Lubell, W. D. "Amino Acid-Azetidine Chimeras: Synthesis of Enantiopure 3-Substituted Azetidine-2-carboxylic Acids" J. Peptide Res. 2005, 63, 298-310.

 

69. Dettwiler, J. E.; Lubell, W. D. "Synthesis and Application of L-N-Boc-N-methyl-beta-hydroxyvaline in the Preparation of a Depsipeptide" Can. J. Chem. 2005, 83, 793–800.

 

68. Bélec, L.; Blankenship, J.W.; Lubell, W. D. “Examination of Structural Characteristics of the Potent Oxytocin Antagonists [dPen1,Pen6]-OT and [dPen1,Pen6,5-tBuPro7]-OT by NMR, Raman, CD Spectroscopy and Molecular Modeling" J. Peptide Sci. 2005, 11, 365-378.

 

67. Cluzeau, J.; Lubell, W. D. "Design, Synthesis and Application of Azabicyclo[X.Y.0] alkanone Amino Acids as Constrained Dipeptide Surrogates and peptide mimics" Biopolymers, Peptide Science, 2005, 80, 98-150.

 

2004

 

66. Jeannotte, G. Lubell, W. D. "Large Structural Modification with Conserved Conformation; Analysis of delta-3-Fused Aryl Prolines in Model beta-Turns" J. Am. Chem. Soc. 2004, 126, 14334-14335.

 

65. Hansford, K. A.; Zanzarova, V.; Dörr, A.; Lubell, W. D. "Three-Step Solution Phase Combinatorial Access to 1,2-Di- and 1,2,5-Trisubstituted Pyrroles from Carboxylic Esters". J. Comb. Chem. 2004, 6, 893-898.

 

64. Gingras, K., Avedissian, H., Thouin, E., Boulangera, V.; Essagiana, C.; McKerracher, L.; Lubell, W. D."Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters" Bioorg. Med. Chem. Lett. 2004, 14, 4931-4934.

 

63. Jeannotte, G. Lubell, W. D. "Synthesis of Fused Heteroarylprolines and Pyrrolopyrroles" J. Org. Chem. 2004, 69, 4656-4662.

 

62. Kaul, R.; Brouillette, Y.; Sajjadi, Z.; Hansford, K. A.; Lubell, W. D. "Selective tert-Butyl Ester Deprotection in the Presence of Acid Labile Protecting Groups with Use of ZnBr2". J. Org. Chem. 2004, 69, 6131-6133.

 

61. Melendez, R. E.; Lubell, W. D. "Aza-Amino Acid Scan for Rapid Identification of Secondary Structure Based on the Application of N-Boc-Aza1-Dipeptides in Peptide Synthesis" J. Am. Chem. Soc. 2004, 126, 6759-6764.

 

60. Van Cauwenberghe, S.; Simonin, F.; Cluzeau, J.;  Becker, J. A. J.; Lubell, W.D.; Tourwé, D. “Structure-Activity Study of the ORL1 Antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-pClPhe-NH2“ J. Med. Chem. 2004, 47, 1864-1867.

 

59. Dettwiler, J. E.; Lubell, W. D. "Diversity-oriented synthesis of enantiopure N-protected β,β-dialkylserines" Can. J. Chem. 2004, 82, 318-324.

 

58. Cluzeau, J.; Lubell, W. D. "Conformationally Constrained Dipeptide Surrogates with Aromatic Side-Chains: Synthesis of 4-Aryl Indolizidin-9-one Amino Acids by Conjugate Addition to a Common a,w-Diaminoazelate Enone Intermediate" J. Org. Chem. 2004, 69, 1504-1512.

 

2003

 

57. Hansford, K.; Dettwiler, J. E.; Lubell, W. D. "One-pot synthesis of homoallylic ketones from the addition of vinyl Grignard reagent to carboxylic esters" Org. Lett. 2003, 5, 4887-4890.

 

56. Dietrich,E.; Lubell,W.D. "Efficient synthesis of Enantiopure pyrrolizidinone amino acid" J. Org. Chem. 2003, 68, 6988-6996.

 

55. Marcotte, F.-A.; Rombouts, F.; Lubell, W. D. "Diversity Oriented Synthesis of Functionalized Pyrrolo[3,2-d]pyrimidines...". J. Org. Chem. 2003, 68, 6984-6987.

 

54. Dettwiler, J. E.; Lubell, W. D. "Serine as Chiral Educt for the Practical Synthesis of Enantiopure N-Protected b-Hydroxyvaline" J. Org. Chem. 2003, 68, 177-179.

 

53. Melendez, R. E.; Lubell, W.D. "Sulfamidites and Sulfamidates" Tetrahedron 2003, 59, 2581-2616.

 

2002

 

52. Peri, K.G.; Quiniou, C.; Hou, X.; Abran, D.; Varma, D.R.; Lubell, W. D.; Chemtob, S. "THG113: a novel selective FP antagonist which delays preterm labor"  Seminars in Perinatology 2002, 26, 389-397.

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51. Halab, L.; Becker, J. A. J.; Darula, Z.; Tourwe, D.; Kieffer, B. L.; Simonin, F.; Lubell, W. D. "Probing Opioid Receptor Interactions with Azacycloalkane Amino Acids.  Synthesis of a Potent and Selective ORL1 Antagonist" J. Med. Chem. 2002, 45, 5353-5357.

 

50. Roy, S.; Lombart,  H.-G.; Hancock, R.E.W.; Farmer, S.W.; Lubell, W.D. "Exploring Relationships Between Mimic Configuration, Peptide Conformation and Biological Activity in Indolizidin-2-one Amino Acid Analogs of Gramicidin S" J. Peptide Res. 2002, 60, 198-214.

 

49. Cluzeau, J.; Lubell, W. D. "Remarkable Asymmetric Induction from Remote Stereocenters in Conjugate Addition Chemistry for the Synthesis of Alkyl-Branched a,w-Diaminoazelates" Israel J. Chem. 2002, 41, 271-281.

 

48. Marcotte, F.-A.; Lubell, W. D. "An effective new synthesis of 4-aminopyrrole-2-carboxylates" Org. Lett. 2002, 4, 2601-2603.

 

47. Miranda, L. P.; Lubell, W. D.; Halkes, K. M.; Groth, T.; Grøtli, M.; Rademan, J.; Gotfredsen, C. H.; Meldal, M. "SPOCC 194, a New High Functional Group Density PEG-Based Resin for Solid-Phase Organic Synthesis" J. Combi. Chem. 2002, 4, 523-529.

 

46. Halab, L.; Lubell, W. D. "Effect of Sequence on Peptide Geometry in 5-tert-Butylproline Type VI b-Turn Mimics." J. Am. Chem. Soc. 2002, 124, 2474-2484.

 

45. Dergham, P.; Ellezam, B.; Avedissian, H.; Essagian, C.; Lubell, W. D.; Mckerracher, L. "Rho signaling pathway targeted for spinal cord repair" J. Neurosci. 2002, 22, 6570-6577.

 

2001

 

44. Atfani, M.; Wei, L.; Lubell, W. D. "N-(9-(9-Phenylfluorenyl))Homoserine-derived Cyclic Sulfamidates: Novel Configurationally Stable Chiral Educts for the Synthesis of Enantiopure gamma-Substituted alpha-Amino Acids" Org. Lett. 2001, 3, 2965-2968.

 

43. Bélec, L.; Maletinska, L.; Slaninova, J.; Lubell, W. D. "The Influence of Steric Interactions on the Conformation and Biology Oxytocin.  Synthesis and Analysis of Penicilamine6-5-tert-Butylproline7-Oxytocin Analogues" J. Peptide Res. 2001, 58, 263-273.

 

42. Halab, L.; Bélec, L.; Lubell, W. D. "Improved Synthesis of (2S, 5S)-trans-5-tert-Butylproline" Symposia-in-Print on Asymmetric Synthesis of Amino Acids. Tetrahedron 2001, 57, 6439-6446.

 

*41. Polyak, F.; Lubell, W. D. "Mimicry of Peptide Back-Bone Geometry and Heteroatomic Side-Chain Functionality: Synthesis of Enantiopure Indolizidin-2-one Amino Acids Possessing Alcohol, Acid and Amine Functional Groups." J. Org. Chem. 2001, 66, 1171-1180.

 

40. Feng, Z.; Lubell, W. D. "Mimicry of Peptide Back-Bone Geometry and Heteroatomic Side-Chain Functionality: Synthesis of 7-[3-Azidopropyl]indolizidin-2-one Amino Acid as a Constrained Ala-Lys Dipeptide Surrogate" J. Org. Chem. 2001, 66, 1181-1185.

 

39. Wei, L.; Lubell, W. D. "Scope and Limitations of N-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of Amino Acids" Can. J. Chem. 2001, 79, 94-104.

 

38. Grøtli, M.; Rademan, J.; Groth, T.; Lubell, W.; Miranda, L.; Meldal, M. "Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-based Resins in Silicon Oil; Beaded SPOCC 1500 and POEPOP 1500" J. Combi. Chem. 2001, 3, 28-33.

 

37. Gosselin, F.; Tourwe, D.; Ceusters, M; Meert, T.; Heylen, L.; Jurzak, M.; Lubell, W. D. "Probing Opioid Receptor-Ligand Interactions by Employment of Indolizidin-9-one Amino Acid as a Constrained Gly2-Gly3 Surrogate in a Leucine-Enkephalin Mimic" J. Peptide Res. 2001, 57, 337-44.

 

36. Halab, L.; Lubell, W. D. "Effect of Stereochemistry on 5-tert-Butylproline Type VI β-Turn Mimics." J. Peptide Sci. 2001, 7, 92-104.

 

2000

 

35. Groth, T.; Grøtli, M.; Lubell, W. D.; Miranda, L.; Meldal, M. HYDRA: A Novel Hydroxy and Amine Functionalised Resin Synthesised by Reductive Amination of PEG Aldehyde and a Polyamine" J. Chem. Soc., Perkin Trans. 1 2000, 4258-4264.

 

34. Khiat, A.; Fournier, A.; Lubell, W.; Boulanger, Y. "Conformational analysis of endothelin-1 analogs with indolizidinone amino acids incorporated at the C-terminus" J. Cardiovasc. Pharmacol. 2000, 36 (Supp.1), S33-S35.

 

33. Mannekens, E.; Tourwe, D.; Lubell, W. D. "Efficient Synthesis of 1-Benzyloxyphenyl-3-phenylacetones" Synthesis 2000 1214-1216.

 

32. Wei, L.; Lubell, W. D. "Racemization in the Use of N-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of d-Keto a-Amino Carboxylates and Prolines" Org. Lett. 2000, 2, 2595-2598.

 

31. Bélec, L.; Slaninova, J.; Lubell, W. D. "A Study of the Relationship between Biological Activity and Prolyl Amide Isomer Geometry in Oxytocin Using 5-tert-Butylproline" J. Med. Chem. 2000, 43, 1448-55.

 

30. Gosselin, F.; Lubell, W. D. "Rigid Dipeptide Surrogates: Syntheses of Enantiopure Quinolizidinone and Pyrroloazepinone Amino Acids from a Common Precursor" J. Org. Chem. 2000, 65, 2163-2171.

 

29. Swarbrick, M. E.; Lubell, W. D. "A Stereoconvergent Approach for Synthesizing Enantiopure 5,6-Dialkylpipecolic Acids" Chirality 2000, 12, 366-373.

 

28. Rondeau, D; Gill, P.; Chan, M.; Curry, K.; Lubell, W. D. "Synthesis and Pharmacology of New Enantiopure ∆3-4-Arylkainoids" Bioorg. Med. Chem. Lett. 2000, 10, 771-773.

 

27. Thouin, E; Lubell, W. D. "Effective synthesis of enantiopure hydroxamates by displacement of oxime resino esters with hydroxylamine" Tetrahedron Lett. 2000, 41, 249-256.

 

26. Beausoleil, E.; Lubell, W. D. "An examination of the Steric Effects of 5-t-BuPro on the Conformation of Polyproline and the Cooperative Nature of Type II to Type I Helical Interconversion" Biopolym. 2000, 53, 249-256.

 

25. Halab, L.; Gosselin, F.; Lubell, W. D. "Design, Synthesis and Conformational Analysis of Azacycloalkane Amino Acids as Conformationally Constrained Probes for Mimicry of Peptide Secondary Structures" Biopolymers, Peptide Science 2000 55, 101-122.

 

1999

 

24. Halab, L.; Lubell, W. D. "The Use of Steric Interactions to Control Peptide Turn Geometry.  Synthesis of Type VI b-Turn Mimics with 5-tert-Butylproline". J. Org. Chem. 1999, 64, 3312-3321.

 

23. Gosselin, F.; van Betsbrugge, J.; Hatam, M.; Lubell, W. D. "A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable a-[N-(Phenylfluorenyl)]Amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support". J. Org. Chem. 1999, 64, 2486-2493.

 

22. Swarbrick, M. E.; Gosselin, F.; Lubell, W. D. "Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of their N-Acetyl N'-Methylamides" J. Org. Chem. 1999, 64, 1993-2002.

 

1998

 

21. Gosselin, F.; Lubell, W. D. "An Olefination Entry for the Synthesis of Enantiopure a,w-Diamino-dicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids." J. Org. Chem. 1998, 63, 7463-7471.

 

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