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Refereed Journal Publications & Reviews



110. Tshibaka, T.; Roche Ulliel, I.; Dufresne, S.; Lubell, W. D.; Skene, W. G. "Unsymmetric Electronic Push-Pull Bipyrroles – Synthesis, Spectroelectrochemical, and Photophysical Investigation" J. Org. Chem. 2009, 74 (24), 9497–9500.


109. Sabatino, D.; Proulx, C.; Klocek, S.; Bourguet, C.B.; Boeglin, D. Ong, H.; Lubell, W.D. “Side-Chain Diversity by Submonomer Solid-Phase Synthesis of Aza-Peptides” Org. Lett. 2009, 11, 3650-3653.


108. Gnaccarini, C.; Ben-Tahar, W.; Pelletier, J.; Lubell, W.D.; Keillor, J.W. “Fluorometric Assay for Transglutaminase-Mediated Transamidation Activity” Bioorg. Med. Chem. 2009, 17, 6354-6359.


107. Rihakova, L.; Quiniou, C.; Hamdan, F.; Kaul, R.; Brault, S.; Hou, X.; Lahaie, I.; Sapieha, P.; Gobeil F Jr.; Hardy, P.; Bouvier, M.; Saragovi, H.; Varma, D. R.; Heveker, N.; Guillon, G.; Lubell, W.D.; Chemtob, S. “VRQ397 (CRAVKY): a novel non-competitive V2 receptor antagonist” Am. J. Physiol. Regulatory Integrative Comp. Physiol., Oct 2009; 297: R1009 - R1018.


106. Kassem, T.; Sabatino, D.; Jia, X.; Zhu, X.X.; Lubell, W.D. “To Rink or not to Rink amide link, that is the question to address for more economical and environmentally sound solid-phase peptide synthesis” Int. J. Peptide Res. Therapeutics 2009, 15, 211–218.


105. Jamieson, A. G.; Boutard, N.; Beauregard, K.; Bodas, M.B; Ong, H.; Quiniou, C.; Chemtob, S.; Lubell, W.D. “Positional Scanning for Peptide Secondary Structure by Systematic Solid-Phase Synthesis of Amino-Lactam Peptides” J. Am. Chem. Soc. 2009, 131, 7917–7927.


104. Fridkin, G.; Boutard, N.; Lubell, W.D. “β,β-Disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives”. J. Org. Chem. 2009, 74, 5603–5606.


103. Pardin, C.; Roy, I.; Chica, R. A.; Bonneil, E.; Thibault, P.; Pelletier, J. N.; Keillor, J. W.; Lubell, W. D. “Photolabeling of Tissue Transglutaminase Reveals Binding Mode of Potent Cinnamoyl Inhibitors” Biochemistry, 2009, 48 (15), 3346–3353.




102. Quiniou, C.; Kooli, E.; Joyal, J-S.;Sapieha, P.; Sennlaub, F.; Lahaie, I.;  Zhuo, S.; Hou, X.; Hardy, P.; Lubell, W.; Chemtob, S. “Interleukin-1 and Ischemic Brain Injury in the Newborn: Development of a Small Molecule Inhibitor of IL-1 Receptor” Semin. Perinatol. 2008, 32, 325-333.


101. Bourguet, C. B.; Sabatino, D.; Lubell, W. D. “Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides” Biopolymers, Peptide Science 2008, 90, 824-831.


100. Pardin, C.; Roy, I.; Keillor, J. W.; Lubell, W. “Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase” Chemical Biology and Drug Design 2008, 72, 189-196.


99. Iden, H. S.; Lubell, W. D. “1,3,5-Tri- and 1,3,4,5-Tetra-substituted 1,4-Diazepin-2-one Solid-Phase Synthesis”, J. Comb. Chem. 2008, 10, 691-699.


98. Deaudelin, P.; Lubell, W.D. “Diastereoselective Pictet-Spengler approach for the synthesis of pyrrolo[3,2-e][1,4]-diazepin-2-one peptide turn mimics” Org. Lett. 2008, 10, 2841-2844.


97. Galaud, F., Blankenship, J.W.; Lubell, W.D. “Crystal Structure Analyses and Reactivity of N-Alkyl and N-Acyl-Dioxathiazinanes” Heterocycles 2008, 76, 1121-1131.


96. Quiniou, C.; Lahaie, I.; Hou, X.; Brault, S.; Beauchamp, M.; Leduc, M.; Heveker, N.; Lubell, W. D.; Sennlaub, F.; Phezhetsky, A,; Chemtob, S. “Characterization of a novel allosteric antagonist of Interleukin-1 receptor: 101.10” The Journal of Immunology, 2008, 180, 6977-6987.


95. Pardin, C.; Chica, R. A.; Pelletier, J. N.; Keillor, J. W.; Lubell, W. D. “Cinnamoyl inhibitors of tissue transglutaminase” J. Org. Chem. 2008, 73, 5766-5775.


94. Keillor, J. W.; Chica, R. A.; Chabot, N.; Vinci, V.; Pardin, C.; Fortin, E.; Gillet, S.M.F.G.; Nakano, Y.; Kaartinen, M. T.; Pelletier, J. N.; Lubell, W. D. “The bioorganic chemistry of transglutaminase – from mechanism to inhibition and engineering” Can. J. Chem. 2008, 86, 271-276.


93. Fridkin, G.; Lubell, W.D. “2-Vinylpyrroles and pyrrolo[3,2-d]pyrimidines from direct addition of aldehydes to 4-amino-pyrrole-2-carboxylate derivatives.” Org. Lett. 2008, 10 (5), 849-852.


92. Jolicoeur, B.; Lubell, W.D. “Prodigiosin Synthesis with Electron Rich 2,2’-Bipyrroles" Can. J. Chem. 2008, 86, 213-218.




91. Dörr, A.; Lubell, W.D. “Homoallylic Ketones and Pyrroles by way of Copper-Catalyzed Cascade Additions of Alkyl-Substituted Vinyl Grignard Reagents to Esters” Can. J. Chem. 2007, 85, 1006-1017.


90. Iden, H. S.; Lubell, W.D. “1,3,5-Trisubstituted 1,4-Diazepin-2-ones” J. Org. Chem. 2007, 72, 8980-8983.


89. Luo, J.; Pardin, C.; Zhu, X.X.; Lubell, W.D. “Preparation, Characterization and Application of Poly(viny alcohol)–graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid Phase Synthesis” J. Comb. Chem. 2007, 9, 582-591.


88. Lama, T.; Seaman, S. E.; Genest, N.; Lubell, W.D. “Importance of the Central Amide in Beta-Turns, Synthesis of Pro-Aib Hydroxyethylene Isosteres and Analysis in Model Beta-Turn Peptides” International Journal of Peptide Research and Therapeutics 2007, 13, 355-366.


87. Luo, J.; Pardin, C.; Zhu, X.X.; Lubell, W.D. “Poly(vinyl alcohol)–graft-Poly(ethylene glycol) Resins and their use in Solid-Phase Synthesis and Supported TEMPO Catalysis” Chem. Commun. 2007, 22, 2136-2138.


86. Dörr, A.; Lubell, W.D. “Synthesis of a new p-Defficient Phenylalanine Derivative from a Common 1,4-Diketone Intermediate and Study of the Influence of Aromatic Density on Prolyl Amide Isomer Population” Biopolymers, Peptide Science 2007, 88, 290-299.


85. Rao, M.H.V.R.; Pinyol, E.O.; Lubell, W.D. “Rigid Dipeptide Mimetics: Synthesis of Enantiopure C6-Functionalized Pyrrolizidinone Amino Acids”, J. Org. Chem. 2007, 72, 736-743.


84. Boeglin, D.; Hamdan, F.F.; Melendez, R.E.; Cluzeau, J.; Laperriere, A.; Bouvier, M.; Lubell, W.D. "CGRP Analogs with Aza- and Indolizidione Amino Acid Residues Reveal Conformational Requirements for Antagonist Activity at the Human Calcitonin Gene-Related Peptide 1 Receptor", J. Med. Chem. 2007, 50, 1401-1408.




83. Jolicoeur, B.; Lubell, W.D. "4-Alkoxy and 4-Amino 2,2’-Bipyrrole Synthesis" Org. Lett. 2006, 8, 6107-6110.


82. Iden, H. S.; Lubell, W.D. “1,4-Diazepinone and Pyrrolodiazepinone Syntheses via Homoallylic Ketones from Cascade Addition of Vinyl Grignard Reagent to α-Aminoacyl-β-amino Esters” Org. Lett. 2006, 8, 3425-3428.


81. Boeglin, D.; Xiang, Z.; Sorenson, N.B.; Wood, M.S.; Haskell-Luevano, C.; Lubell, W.D. “Aza-scan of the Potent Melanocortin Receptor Agonist Ac-His-d-Phe-Arg-Trp-NH2” Chem. Biol. Drug Des. 2006, 67, 275–283.


80. Surprenant, S.; Lubell, W. D. “From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids: A Transannular Cyclization Route for Peptide Mimic Synthesis” Org. Lett. 2006, 8, 2851-2854.


79. Surprenant, S.; Lubell, W. D. “9-(4-Bromophenyl)-9-fluorenyl as a Safety-Catch Nitrogen Protecting Group” J. Org. Chem. 2006, 71 (2), 848-851.


78. Brouillette, Y.; Rombouts, F. J. R.; Lubell, W. D. "Solid-Phase Synthesis of 3-Aminopyrrole-2,5-dicarboxylate Analogs" J. Comb. Chem. 2006, 8 (1), 117-126.


77. B. Jolicoeur, E. E. Chapman, A. Thompson, and W. D. Lubell “Pyrrole Protection” Tetrahedron 2006, 62, 11531-11563.




76. Hansford, K. A.; Guarin, S. A. P., Skene, W. G.; Lubell, W. D. "Bis(pyrrol-2-yl)arylenes from the Tandem Bi-directional Addition of Vinyl Grignard Reagent to Aryldiesters" J. Org. Chem. 2005, 70, 7996-8000.


75. Boeglin, D.; Lubell, W. D. "Aza-Amino Acid Scanning of Secondary Structure Suited for Solid-Phase Peptide Synthesis with Fmoc Chemistry and Aza-Amino Acids with Heteroatomic Side-Chains"  J. Comb. Chem. 2005, 7 (6), 864-878.


74. Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: Combinatorial synthesis of a library of N3, N5, C6 trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7 (6), 977-986.


73. Rombouts, F. J. R.; Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7, 589-598.


72. Kaul, R.; Surprenant, S. Lubell, W. D. "Systematic Study of the Synthesis of Macrocyclic Dipeptide Beta-Turn Mimics Possessing 8-, 9- and 10- Membered Rings by Ring Closing Metathesis" J. Org. Chem. 2005, 70, 3838-3844 and addition/correction 2005; 70 (12), 4901-4902.


71. Galaud, F.; Lubell, W. D. "Homoserine-Derived Cyclic Sulfamidate as Chiral Educt for The Diversity Oriented Synthesis of Lactam-Bridged Dipeptides" Biopolymers, Peptide Science, 2005, 80, 665-674.


70. Sajjadi, Z.; Lubell, W. D. "Amino Acid-Azetidine Chimeras: Synthesis of Enantiopure 3-Substituted Azetidine-2-carboxylic Acids" J. Peptide Res. 2005, 63, 298-310.


69. Dettwiler, J. E.; Lubell, W. D. "Synthesis and Application of L-N-Boc-N-methyl-beta-hydroxyvaline in the Preparation of a Depsipeptide" Can. J. Chem. 2005, 83, 793–800.


68. Bélec, L.; Blankenship, J.W.; Lubell, W. D. “Examination of Structural Characteristics of the Potent Oxytocin Antagonists [dPen1,Pen6]-OT and [dPen1,Pen6,5-tBuPro7]-OT by NMR, Raman, CD Spectroscopy and Molecular Modeling" J. Peptide Sci. 2005, 11, 365-378.


67. Cluzeau, J.; Lubell, W. D. "Design, Synthesis and Application of Azabicyclo[X.Y.0] alkanone Amino Acids as Constrained Dipeptide Surrogates and peptide mimics" Biopolymers, Peptide Science, 2005, 80, 98-150.




66. Jeannotte, G. Lubell, W. D. "Large Structural Modification with Conserved Conformation; Analysis of delta-3-Fused Aryl Prolines in Model beta-Turns" J. Am. Chem. Soc. 2004, 126, 14334-14335.


65. Hansford, K. A.; Zanzarova, V.; Dörr, A.; Lubell, W. D. "Three-Step Solution Phase Combinatorial Access to 1,2-Di- and 1,2,5-Trisubstituted Pyrroles from Carboxylic Esters". J. Comb. Chem. 2004, 6, 893-898.


64. Gingras, K., Avedissian, H., Thouin, E., Boulangera, V.; Essagiana, C.; McKerracher, L.; Lubell, W. D."Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters" Bioorg. Med. Chem. Lett. 2004, 14, 4931-4934.


63. Jeannotte, G. Lubell, W. D. "Synthesis of Fused Heteroarylprolines and Pyrrolopyrroles" J. Org. Chem. 2004, 69, 4656-4662.


62. Kaul, R.; Brouillette, Y.; Sajjadi, Z.; Hansford, K. A.; Lubell, W. D. "Selective tert-Butyl Ester Deprotection in the Presence of Acid Labile Protecting Groups with Use of ZnBr2". J. Org. Chem. 2004, 69, 6131-6133.


61. Melendez, R. E.; Lubell, W. D. "Aza-Amino Acid Scan for Rapid Identification of Secondary Structure Based on the Application of N-Boc-Aza1-Dipeptides in Peptide Synthesis" J. Am. Chem. Soc. 2004, 126, 6759-6764.


60. Van Cauwenberghe, S.; Simonin, F.; Cluzeau, J.;  Becker, J. A. J.; Lubell, W.D.; Tourwé, D. “Structure-Activity Study of the ORL1 Antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-pClPhe-NH2“ J. Med. Chem. 2004, 47, 1864-1867.


59. Dettwiler, J. E.; Lubell, W. D. "Diversity-oriented synthesis of enantiopure N-protected β,β-dialkylserines" Can. J. Chem. 2004, 82, 318-324.


58. Cluzeau, J.; Lubell, W. D. "Conformationally Constrained Dipeptide Surrogates with Aromatic Side-Chains: Synthesis of 4-Aryl Indolizidin-9-one Amino Acids by Conjugate Addition to a Common a,w-Diaminoazelate Enone Intermediate" J. Org. Chem. 2004, 69, 1504-1512.




57. Hansford, K.; Dettwiler, J. E.; Lubell, W. D. "One-pot synthesis of homoallylic ketones from the addition of vinyl Grignard reagent to carboxylic esters" Org. Lett. 2003, 5, 4887-4890.


56. Dietrich,E.; Lubell,W.D. "Efficient synthesis of Enantiopure pyrrolizidinone amino acid" J. Org. Chem. 2003, 68, 6988-6996.


55. Marcotte, F.-A.; Rombouts, F.; Lubell, W. D. "Diversity Oriented Synthesis of Functionalized Pyrrolo[3,2-d]pyrimidines...". J. Org. Chem. 2003, 68, 6984-6987.


54. Dettwiler, J. E.; Lubell, W. D. "Serine as Chiral Educt for the Practical Synthesis of Enantiopure N-Protected b-Hydroxyvaline" J. Org. Chem. 2003, 68, 177-179.


53. Melendez, R. E.; Lubell, W.D. "Sulfamidites and Sulfamidates" Tetrahedron 2003, 59, 2581-2616.




52. Peri, K.G.; Quiniou, C.; Hou, X.; Abran, D.; Varma, D.R.; Lubell, W. D.; Chemtob, S. "THG113: a novel selective FP antagonist which delays preterm labor"  Seminars in Perinatology 2002, 26, 389-397.

51. Halab, L.; Becker, J. A. J.; Darula, Z.; Tourwe, D.; Kieffer, B. L.; Simonin, F.; Lubell, W. D. "Probing Opioid Receptor Interactions with Azacycloalkane Amino Acids.  Synthesis of a Potent and Selective ORL1 Antagonist" J. Med. Chem. 2002, 45, 5353-5357.


50. Roy, S.; Lombart,  H.-G.; Hancock, R.E.W.; Farmer, S.W.; Lubell, W.D. "Exploring Relationships Between Mimic Configuration, Peptide Conformation and Biological Activity in Indolizidin-2-one Amino Acid Analogs of Gramicidin S" J. Peptide Res. 2002, 60, 198-214.


49. Cluzeau, J.; Lubell, W. D. "Remarkable Asymmetric Induction from Remote Stereocenters in Conjugate Addition Chemistry for the Synthesis of Alkyl-Branched a,w-Diaminoazelates" Israel J. Chem. 2002, 41, 271-281.


48. Marcotte, F.-A.; Lubell, W. D. "An effective new synthesis of 4-aminopyrrole-2-carboxylates" Org. Lett. 2002, 4, 2601-2603.


47. Miranda, L. P.; Lubell, W. D.; Halkes, K. M.; Groth, T.; Grøtli, M.; Rademan, J.; Gotfredsen, C. H.; Meldal, M. "SPOCC 194, a New High Functional Group Density PEG-Based Resin for Solid-Phase Organic Synthesis" J. Combi. Chem. 2002, 4, 523-529.


46. Halab, L.; Lubell, W. D. "Effect of Sequence on Peptide Geometry in 5-tert-Butylproline Type VI b-Turn Mimics." J. Am. Chem. Soc. 2002, 124, 2474-2484.


45. Dergham, P.; Ellezam, B.; Avedissian, H.; Essagian, C.; Lubell, W. D.; Mckerracher, L. "Rho signaling pathway targeted for spinal cord repair" J. Neurosci. 2002, 22, 6570-6577.




44. Atfani, M.; Wei, L.; Lubell, W. D. "N-(9-(9-Phenylfluorenyl))Homoserine-derived Cyclic Sulfamidates: Novel Configurationally Stable Chiral Educts for the Synthesis of Enantiopure gamma-Substituted alpha-Amino Acids" Org. Lett. 2001, 3, 2965-2968.


43. Bélec, L.; Maletinska, L.; Slaninova, J.; Lubell, W. D. "The Influence of Steric Interactions on the Conformation and Biology Oxytocin.  Synthesis and Analysis of Penicilamine6-5-tert-Butylproline7-Oxytocin Analogues" J. Peptide Res. 2001, 58, 263-273.


42. Halab, L.; Bélec, L.; Lubell, W. D. "Improved Synthesis of (2S, 5S)-trans-5-tert-Butylproline" Symposia-in-Print on Asymmetric Synthesis of Amino Acids. Tetrahedron 2001, 57, 6439-6446.


*41. Polyak, F.; Lubell, W. D. "Mimicry of Peptide Back-Bone Geometry and Heteroatomic Side-Chain Functionality: Synthesis of Enantiopure Indolizidin-2-one Amino Acids Possessing Alcohol, Acid and Amine Functional Groups." J. Org. Chem. 2001, 66, 1171-1180.


40. Feng, Z.; Lubell, W. D. "Mimicry of Peptide Back-Bone Geometry and Heteroatomic Side-Chain Functionality: Synthesis of 7-[3-Azidopropyl]indolizidin-2-one Amino Acid as a Constrained Ala-Lys Dipeptide Surrogate" J. Org. Chem. 2001, 66, 1181-1185.


39. Wei, L.; Lubell, W. D. "Scope and Limitations of N-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of Amino Acids" Can. J. Chem. 2001, 79, 94-104.


38. Grøtli, M.; Rademan, J.; Groth, T.; Lubell, W.; Miranda, L.; Meldal, M. "Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-based Resins in Silicon Oil; Beaded SPOCC 1500 and POEPOP 1500" J. Combi. Chem. 2001, 3, 28-33.


37. Gosselin, F.; Tourwe, D.; Ceusters, M; Meert, T.; Heylen, L.; Jurzak, M.; Lubell, W. D. "Probing Opioid Receptor-Ligand Interactions by Employment of Indolizidin-9-one Amino Acid as a Constrained Gly2-Gly3 Surrogate in a Leucine-Enkephalin Mimic" J. Peptide Res. 2001, 57, 337-44.


36. Halab, L.; Lubell, W. D. "Effect of Stereochemistry on 5-tert-Butylproline Type VI β-Turn Mimics." J. Peptide Sci. 2001, 7, 92-104.




35. Groth, T.; Grøtli, M.; Lubell, W. D.; Miranda, L.; Meldal, M. HYDRA: A Novel Hydroxy and Amine Functionalised Resin Synthesised by Reductive Amination of PEG Aldehyde and a Polyamine" J. Chem. Soc., Perkin Trans. 1 2000, 4258-4264.


34. Khiat, A.; Fournier, A.; Lubell, W.; Boulanger, Y. "Conformational analysis of endothelin-1 analogs with indolizidinone amino acids incorporated at the C-terminus" J. Cardiovasc. Pharmacol. 2000, 36 (Supp.1), S33-S35.


33. Mannekens, E.; Tourwe, D.; Lubell, W. D. "Efficient Synthesis of 1-Benzyloxyphenyl-3-phenylacetones" Synthesis 2000 1214-1216.


32. Wei, L.; Lubell, W. D. "Racemization in the Use of N-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of d-Keto a-Amino Carboxylates and Prolines" Org. Lett. 2000, 2, 2595-2598.


31. Bélec, L.; Slaninova, J.; Lubell, W. D. "A Study of the Relationship between Biological Activity and Prolyl Amide Isomer Geometry in Oxytocin Using 5-tert-Butylproline" J. Med. Chem. 2000, 43, 1448-55.


30. Gosselin, F.; Lubell, W. D. "Rigid Dipeptide Surrogates: Syntheses of Enantiopure Quinolizidinone and Pyrroloazepinone Amino Acids from a Common Precursor" J. Org. Chem. 2000, 65, 2163-2171.


29. Swarbrick, M. E.; Lubell, W. D. "A Stereoconvergent Approach for Synthesizing Enantiopure 5,6-Dialkylpipecolic Acids" Chirality 2000, 12, 366-373.


28. Rondeau, D; Gill, P.; Chan, M.; Curry, K.; Lubell, W. D. "Synthesis and Pharmacology of New Enantiopure ∆3-4-Arylkainoids" Bioorg. Med. Chem. Lett. 2000, 10, 771-773.


27. Thouin, E; Lubell, W. D. "Effective synthesis of enantiopure hydroxamates by displacement of oxime resino esters with hydroxylamine" Tetrahedron Lett. 2000, 41, 249-256.


26. Beausoleil, E.; Lubell, W. D. "An examination of the Steric Effects of 5-t-BuPro on the Conformation of Polyproline and the Cooperative Nature of Type II to Type I Helical Interconversion" Biopolym. 2000, 53, 249-256.


25. Halab, L.; Gosselin, F.; Lubell, W. D. "Design, Synthesis and Conformational Analysis of Azacycloalkane Amino Acids as Conformationally Constrained Probes for Mimicry of Peptide Secondary Structures" Biopolymers, Peptide Science 2000 55, 101-122.




24. Halab, L.; Lubell, W. D. "The Use of Steric Interactions to Control Peptide Turn Geometry.  Synthesis of Type VI b-Turn Mimics with 5-tert-Butylproline". J. Org. Chem. 1999, 64, 3312-3321.


23. Gosselin, F.; van Betsbrugge, J.; Hatam, M.; Lubell, W. D. "A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable a-[N-(Phenylfluorenyl)]Amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support". J. Org. Chem. 1999, 64, 2486-2493.


22. Swarbrick, M. E.; Gosselin, F.; Lubell, W. D. "Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of their N-Acetyl N'-Methylamides" J. Org. Chem. 1999, 64, 1993-2002.




21. Gosselin, F.; Lubell, W. D. "An Olefination Entry for the Synthesis of Enantiopure a,w-Diamino-dicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids." J. Org. Chem. 1998, 63, 7463-7471.


20. Beausoleil, E.; Sharma, R.; Michnick, S.; Lubell, W. D. "Alkyl 3-Position Substituents Retard the Isomerization of Prolyl and Hydroxyprolyl amides in water". J. Org. Chem. 1998, 63, 6572-8.


19. Polyak, F.; Lubell, W. D. "Rigid Dipeptide Mimics: Synthesis of Enantiopure 5- and 7-Benzyl, and 5,7-Dibenzyl Indolizidinone Amino Acids Via Enolization and Alkylation of d-Oxo a,w-Di-[N-(9-(9-phenylfluorenyl))amino]azelate Esters." J. Org. Chem. 1998, 63, 5937-5949.



18. Hanessian, S.; Mcnaughtonsmith, G; Lombart, H.-G.; Lubell, W. D. "Design and Synthesis of Conformationally Constrained Amino Acids as Versatile Scaffolds and Peptide Mimetics". Tetrahedron 1997, 53, 12789-12854.



17. Lombart, H.-G.; Lubell, W. D. "Rigid Dipeptide Mimetics.  Efficient Synthesis of Enantiopure Indolizidinone Amino Acids". J. Org. Chem. 1996, 61, 9437-9446.


16. Beausoleil, E.; l'Archevêque, B.; Bélec, L.; Atfani, M.; Lubell, W. D. "5-tert-Butylproline". J. Org. Chem. 1996, 61, 9447-9454.


15. Beausoleil, E.; Lubell, W. D. "Steric Effects on the Amide Isomer Equilibrium of Prolyl Peptides. Synthesis & Conformational Analysis of N-Ac-5-tert-Butylproline N'-Methylamides". J. Am. Chem. Soc. 1996, 118, 12902-12908.


14. Gosselin, F.; Di Renzo, M.; Ellis, T. Lubell, W. D. "Photoacoustic FT-IR, A Non-Destructive Method for Sensitive Spectroscopic Analysis of Solid-Phase Org. Chem.". J. Org. Chem. 1996, 61, 7980-7981


13. Sharma, R.; Lubell, W. D. "Regioselective Enolization and Alkylation of 4-Oxo-N-(9-phenylfluoren-9-yl)proline: Synthesis of Enantiopure Proline-Valine and Hydroxyproline-Valine Chimeras". J. Org. Chem. 1996, 61, 202-209.



12. Gill, P.; Lubell, W. D. "Synthesis of Enantiopure Arylkainoids; Preparation of (2S)-∆3-4-Phenylkainic Acid". J. Org. Chem. 1995, 60, 2658-2659.


11. Atfani, M.; Lubell, W. D. "Synthesis of (S)-2-Amino-3-(3-tert-butyl-4-isoxazol-5(2H)-one)propionic acid". J. Org. Chem. 1995, 60, 3184-3188.


10. Kitamura, M.; Tokunaga, M.; Pham, P.; Lubell, W. D.; Noyori, R. "Asymmetric Synthesis of a-Amino b-Hydroxy Phosphonic Acids Via BINAP–Ruthenium Catalyzed Hydrogenation". Tetrahedron Lett. 1995, 36, 5769-5772.


9. Lombart, H.-G.; Lubell, W. D. "Synthesis of Enantiopure a,w-Diamino Dicarboxylates and Azabicycloalkane Amino Acids by Claisen Condensation of a-N-(phenylfluorenyl)amino Dicarboxylates". J. Org. Chem. 1994, 59, 6147-6149.


8. Pham, T.; Lubell, W. D. "A Practical Enantioselective Synthesis of a-Aminodicarboxylates.  Preparation of D- and L-a-Aminoadipate, a-Aminopimelate, and a-Aminosuberate". J. Org. Chem. 1994, 59, 3676 - 3680.



7. Ibrahim, H. H.; Lubell, W. D. "Synthesis of Enantiopure d-Oxo a-Amino Esters and Prolines Via Acylation of N-Phenylfluorenylglutamate Enolates". J. Org. Chem. 1993, 58, 6438 - 6441.


6. Jamison, T. F.; Lubell, W. D.; Dener, J. M.; Krisché, M. J.; Rapoport, H. "Synthesis of 9-Bromo-9-phenylfluorene". Org. Syn. 1992, 71, 220 - 235.


5. Lubell, W. D.; Kitamura, M.; Noyori, R. "Enantioselective Synthesis of b-Amino Acids Based on binap – Ruthenium(II) Catalyzed Hydrogenation". Tetrahedron: Asymm. 1991, 2, 543-554.



4. Lubell, W. D.; Jamison, T. F.; Rapoport, H. "N-(9-Phenylfluoren-9-yl)a-Amino Ketones and a-Amino Aldehydes as Chiral Educts for the Synthesis of Optically Pure 4-Alkyl 3-Hydroxy 2-Amino Acids.  Synthesis of the C-9 Amino Acid, MeBmt, Present in Cyclosporin".  J. Org. Chem. 1990, 55, 3511-3522. 



3. Lubell, W. D.; Rapoport, H. "Surrogates for Chiral Aminomalondialdehyde.  Synthesis of N-(9-Phenylfluoren-9-yl)serinal and N-(9-Phenylfluoren-9-yl)vinylglycinal". J. Org. Chem. 1989, 54, 3824-3831. 



2. Lubell, W. D.; Rapoport, H. "a-Amino Acids as Chiral Educts for Asymmetric Products.  Alkylation of N-Phenylfluorenyl a-Amino Ketones.  Synthesis of a-Alkyl Substituted Carboxylic Acids". J. Am. Chem. Soc. 1988, 110, 7447-7455. 



1. Lubell, W. D.; Rapoport, H.  "Configurational Stability of N-Protected a-Amino Aldehydes ". J. Am. Chem. Soc. 1987, 109, 236-239. 

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